Lysosome acidification by photoactivated nanoparticles restores autophagy under lipotoxicity
نویسندگان
چکیده
منابع مشابه
Lysosome acidification by photoactivated nanoparticles restores autophagy under lipotoxicity
In pancreatic β-cells, liver hepatocytes, and cardiomyocytes, chronic exposure to high levels of fatty acids (lipotoxicity) inhibits autophagic flux and concomitantly decreases lysosomal acidity. Whether impaired lysosomal acidification is causally inhibiting autophagic flux and cellular functions could not, up to the present, be determined because of the lack of an approach to modify lysosomal...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2016
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.201511042